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Participants, who had heart disease or were at increased risk for it, were randomly assigned to celecoxib (100 mg twice a day), ibuprofen (600 mg three times a day) or naproxen (375 mg twice a day), which they took for at least 18 months. There was no significant difference in the occurrence of heart attack, stroke or death between the three groups. One limitation of the study was the high number of people who dropped out. However, the drop-out rate was similar for all three groups, so I dont think it affects the overall conclusions, says Dr. Husni.