If youre like most people with rheumatoid arthritis (RA), you take a combination of medications to counter your immune systems attack on your joints. And like those other RA patients, the drug regimen you use to manage your condition today may not be the same a year from now. The effectiveness of RA medications varies from person to person, and over time the efficacy of a particular drug may decline. This loss of effectiveness occurs in many RA patients, and for a variety of reasons. Not all of the drugs work for everybody. Some patients do well initially and then lose efficacy, and the majority of people never attain complete remission, says rheumatologist Chad Deal, MD, Head of the Center for Osteoporosis and Metabolic Bone Disease at Cleveland Clinic.