Having gout could make nighttime more painful. A study published online in Arthritis & Rheumatology (Dec. 2014) found that the risk of a gout attack was more than double during the night compared with daytime hours. When reviewing 724 adult patients with gout, researchers found that attacks occurred more frequently from midnight to 8 a.m., compared with the period between 8 a.m. and 4 p.m. The risk of a gout attack was also somewhat higher from 4 p.m. until midnight, the study found. The significantly higher risk between midnight and 8 a.m. was found among alcohol users and those who take diuretic medications. Patients taking allopurinol (Zyloprim) and colchicine were also at increased risk of attacks during the nighttime hours.