Naltrexone is commonly prescribed for alcohol use disorder or opioid use disorder but may be effective on chronic pain at low doses. “Our understanding of the mechanism is that these lower doses of naltrexone temporarily block opioid receptors, which triggers the brain to produce more natural painkillers called endorphins and enkephalins,” says Annabelle Hood, Pharm-D, BCACP, Cleveland Clinic clinical pharmacy specialist in pain management.
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