Rheumatoid arthritis (RA) causes pain, swelling and stiffness in joints. But RA can cause other symptoms as well, one of the most common of which is fatigue. Fatigue with RA differs from tiredness anyone can feel from time to time, for example after a bad night of sleep. Its a feeling of exhaustion all the time. It may interfere with your ability to go about normal daily activities and function effectively at work.