While they can be very effective, biologics have some drawbacks. Most of them must be taken by injection or intravenous infusion, and there are potential side effects, some of which can be serious. In most cases, the benefits will outweigh the risks, says Dr. Bunyard. But it may take some trial and error to find the right drug or combination of drugs that leads to remission or low disease activity without any unacceptable side effects.If you are on a regimen of drugs for rheumatoid arthritis and are still experiencing pain or dysfunction, it may be time to make a change. But Dr. Bunyard notes that increased pain and dysfunction may also stem from a different cause.