Bones & JointsFull Issue PDFPain ManagementSubscriber Only Download The Full October 2019 Issue PDF NSAIDs are effective because they block an enzyme called cyclooxygenase (COX), which exists in two forms-COX-1 and COX-2. These enzymes make chemicals called prostaglandins, which contribute to inflammation in the body. To continue reading this article you must be a paid subscriber Subscribe Subscribe to Arthritis Advisor Get the next year of Arthritis Advisor for just $20. And access all of our online content - over 1,000 articles - free of charge. Subscribe today and save 36%. It's like getting 4 months FREE! Already Subscribed? Click Here to Sign In | Forgot your password?