There are inherent difficulties in studying any treatments for osteoarthritis. First is the placebo effect. Some people will get better even when given an inactive treatment simply because they believe it will work.It is also tricky to evaluate any treatment for osteoarthritis because symptoms do not always steadily worsen. Instead, pain tends to come and go. It may not be clearly evident whether an improvement was the result of a treatment or the natural ebbing and flowing of symptoms.