There is no cure for osteoarthritis, which can worsen over time. Treatment is aimed at relieving symptoms. The most effective treatment is weight loss if you are above ideal weight, says Dr. Day. Physical therapy, exercise and knee braces can help. Other options are nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen (Tylenol), supplements, and injections of corticosteroids or hyaluronic acid.