For mild-to-moderate pain of osteoarthritis, especially in the hands and possibly knees, topical non-steroidal anti-inflammatory drugs (NSAIDs) can be effective for pain relief. Some studies show they relieve pain as well as their oral counterparts, and they may be less irritating on the stomach. When wrist pain is a result of carpal tunnel syndrome there usually is numbness in addition to pain. There are other possibilities to consider as a cause of wrist pain.
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